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This protocol for the preparation of aryl silanes is characterized by its mild conditions and wide substrate scope of inert fluoroarenes.
Several examinations already revealed the wide substrate scope of the hydantoinase of A. crystallopoietes DSM20117 concerning hydantoins (Siemann et al. 1999).
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Of particular significance are the superior activity and wider substrate scope of the catalyst, in relation to other known supported noble metals, and the excellent recyclability and long catalyst lifetime.
Despite the demonstration of wide substrate scope for the Suzuki Miyaura cascade with alkenylboronic acids and esters, it was clear that we might yet improve on several aspects of this reaction.
The binary catalyst system also showed broad substrate scope of epoxide.
Comparably wide substrate scope was attained with satisfactory levels of diastereo- and enantioselectivities from substrates containing thioketene silyl acetals.
Carreira has described particularly useful asymmetric methodology with silyl ketene acetals, noteworthy for its high levels of enantioselectivity and wide substrate scope.
Ambient reaction conditions, wide substrate scope, and facile accessibility to the starting materials, are some of the other outstanding features of this protocol that make it economic and sustainable.
A wide substrate scope was demonstrated for the cross-coupling; a slight erosion of ee is observed when R = Me.
The reaction has a wide substrate scope including tertiary, secondary and certain primary allylic alcohols, and tolerates a wide range of substituents on the thiol nucleophile.
A catalytic amount of lanthanide triflates worked well and high yields with wide substrate scope were obtained.
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