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Recently a number of different platforms have been developed for carrying out large scale parallel sequencing in order to generate genome wide sequences in a short time and reduced cost [ 41- 43].
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Analysis of genomic diversity within all P. falciparum infection samples analysed from six West African countries using genome wide sequence data.
We obtained from dbEST a number of mismatches roughly 5 times higher than the genome wide sequencing screens.
In this study we have employed a genome wide sequencing technique to identify mitochondrial mutations in adenoid cystic carcinoma.
With the sequences of complete genomes available [1] [4], and accelerating technologies for high-throughput sequencing [5] genome wide sequence analyses of individual samples will soon become reality.
Until recently, genome wide sequencing has been cost limited to relatively few species.
Besides changes in number, N. vitripennis also undergoes wide sequence extension.
This approach shows promise for the analysis of data currently emerging from genome wide sequencing studies.
However, the size of the M-core (141 individuals) limits its use for the analysis of wide sequence diversity.
High coverage genome wide sequence data for 85 different clinical isolates enabled analysis of 121,712 single nucleotide polymorphisms (SNPs).
Toward the objective of characterizing HCV evolution during the natural disease course in humans, the present study derived near genome-wide sequences of HCV genomes that circulated over time in 9 chronically infected research subjects, all of whom were monoinfected with HCV genotype 1.
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