These studies indicate the feasibility of mutagenizing this organism with the purpose of conducting unbiased, genome-wide scale screens of conditionally essential genes of MAP.
However, wide-scale screening for GBS colonization may be difficult to implement.
This suggests that financial issues should be taken into consideration when a wide-scale screening program is introduced in Kinshasa.
For this reason, many lignocellulosic biofuel research initiatives include large-scale screening of the saccharification properties of wide germplasm collections of crops with potential use for second generation biofuel production.
Since completing this investigation, AMPATH has partnered with the Kenyan Ministry of Health to begin wide scale implementation of a diabetes and hypertension screening program.
In order to get rid of false positives that are expected to be selected in this type of large-scale screen of a genome-wide pool of ORFs, the next step of the screening procedure consisted in individually testing all candidates in conventional growth assays [13].
The greatest single barrier toward wide-scale population screening and prevention of the disease is the hitherto lack of an effective intervention.
It's more of a proof-of-concept on a wide scale.
The screen was conducted with a library of siRNAs against 646 kinases and associated proteins, and is currently expanded to a genome wide scale.
A wide screening of commercially available materials is thus required to evaluate them as alternatives.
Computational screens for structured RNAs result in thousands of candidates on a genome-wide scale and it is of interest to predict possible RNA interaction partners of these sequences (Gorodkin et al., 2010; Gorodkin and Hofacker, 2011).
