Notably, the ERE sites genotyped have been shown to bind ERα in vivo using ChIP-based methods on a genome-wide scale, providing a unique opportunity to comprehensively examine putative ERE sites without depending on an a priori hypothesis.
The expression profiles in genome-wide scale provide essential data for building the co-expression network, thus allowed us to identify biological processes and gene functions [ 17].
However, cap and trade programs have been practiced on a smaller scale, providing hope that a program could be implemented in a wider region in the future.
All symptom dimensions (frequency, severity and distress) were rated on a 0-10 point scale because this type of response scale is easier for patients to use (i.e. similar to the commonly used numerical pain rating scale), provides a wider range of possible scores, and increases the statistical analyses that are available.
Although functional genomic methods have provided considerable advances to our understanding of gene regulation, these assays, which are usually performed on a genome-wide scale, typically provide correlative observations that lack functional interpretation.
We identify messenger RNAs associated with C. briggsae GLD-1 on a genome-wide scale and provide evidence that many participate in aspects of germline development.
Studying the coordination patterns between alternative exons and their functional importance on a genome-wide scale can provide valuable information for our understanding of alternative splicing.
The development of DNase I hypersensitivity mapping at the genome-wide scale has provided new approaches to characterize CRMs and the transcription factors that recognize them [ 22, 23].
In the last few years, different high-throughput methods have been implemented on a genome-wide scale to provide detailed spatial maps of gene expression, both at the mRNA and protein levels.
The methodology proposed here to analyze the in vivo dynamics of transcription may be applicable at a genome-wide scale and provide valuable insight into the dynamics of prokaryotic genetic networks.
Predicting disordered regions from amino acid sequence allows the analysis of disordered proteins at a genome-wide scale and provides initial hypotheses about the presence of structural disorder in individual proteins.
