Interestingly, no significant overlap between the gene sets identified from the loss and gain of function experiments was found, suggesting that on a genome-wide scale loss of function and over expression do not produce related phenotypes.
We observed that, on a genome-wide scale, loss of MOP1 resulted in an increase in chromatin accessibility/sensitivity at gene-rich chromosome arms; whereas pericentromeric regions were less accessible/more resistant.
"It's the only city in America where we've had two teams for 40-plus years, it's the only city in America where we have 500 employees and thousands of family members, and," his voice rising for emphasis, "it's the only city in America that was hit by terrorists and caused wide-scale loss of life.
Such an admixed gene pool could be an important source of genetic information on pathogen evolution in real time to possibly understand how gene acquisition and loss on a population wide scale shape virulence and fitness in different pathogens.
Conservation on a wide scale takes more than good ideas.
"Wall-E" has not opened on a wide scale internationally.
He has already signalled he anticipates wide scale change.
How can it be adopted on a wide scale?
"This many tornadoes on such a wide scale is overwhelming".
No one really knows yet whether this idea will actually fly on a wide scale.
"My personal experiences with health data on a wide scale?
