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Although this present approach is to our knowledge the first whole genome cross-species approach for invasion, several other cross-species comparisons on a more or less genome- wide scale have been performed.
IBM on a more wider scale has been putting itself in front of the car industry by doing things like partnering with and sponsoring the organization that runs the big auto show in Detroit in January.
A powerful approach to the identification of sRNAs on a genome-wide scale has been the recent use of tiling microarrays [24], [25].
To the best of our knowledge, though target identification on a genome-wide scale has been performed [3], there are no quantitative results we can compare with.
To our knowledge, this is the first report where quantitative information about particular splice variants at a genome-wide scale has been generated for different anatomical segments of normal and AD brains.
The use of microarray technology to measure gene expression on a genome-wide scale has been well established for more than a decade.
Also, the structural roles of polar sidechains, the identification of motifs in helix interactions and the significance of certain topologies on a genome-wide scale have been further explored.
However, only eight studies addressing the mechanisms determining mRNA half-life at the genome-wide scale have been published.
Multiple methodologies on a genome-wide scale have been used, including RDA, CGH, and more recently: CNV calling using next generation sequencing [ 1].
A number of experimental approaches to compile TSSs on a genome-wide scale have been developed including the Eukaryotic Promoter Database [ 25, 26] and PlantProm Database [ 27].
Wide-angle reflection refraction profiles at crustal scale have been obtained along a 700 km transect of northeastern Tibet from six shotpoints.
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