However, inter-patient and even intratumoural heterogeneity, as well as cost factors have precluded wide-scale clinical application.
However, inter-patient and even intratumoural heterogeneity, as well as cost factors and a lack of validation have precluded wide-scale clinical application (Shibayama et al, 2011).
Immuno-PET has reached maturity in terms of technical development and is now entering the phase of wide-scale clinical applications.
There are two models available in the range: the wide temperature units with humidity control (available in 311 L and 821 L) and a heat-only model (available in 821 L) that is tailored for large-scale clinical applications and microbiology.
In this respect, radiolabeled nitroimidazole compounds find wide clinical application [14].
This may be one reason why it did not find wide clinical application to date.
These peptides may offer a wide clinical application in quickly proliferating tumours [ 86, 87].
Hyaluronic acid (HA) is another biocompatible anionic biopolymer used in a wide array of clinical application.
It can be prepared by plasmapheresis, but for a wide clinical application it may result unpractical.
These features in combination with hepatic and systemic toxicity are major drawbacks toward wide clinical application.
The scale's clinical application awaits validation in a larger population.
