For example, if trying to infer protein-protein interactions on a genome-wide scale based on coevolutionary relationships, true positives would not be known.
While it has previously been demonstrated that a subset of miRNA genes are under the same type of extreme long-range transcriptional regulation typical for developmental transcription factors [ 17], we were now able to identify further putative GRB target miRNAs on a genome-wide scale based on the same characteristics defining protein-coding GRB target genes.
IGENT, Interactions analysis method in Genome-wide scale based on ENTropy; WTCCC, the Wellcome Trust Case Control Consortium BDD, Bipolar disorder; SVM, support vector machine; RF, random forest; GGI, gene-gene interaction; IG, information gain; The authors declare that they have no competing interests.
They enable successful implementation of Quality by Design by allowing us to investigate more variables and wider ranges than would be possible using traditional lab-scale based experiments.
Particularly in resource-limited settings, it may be unrealistic to model the cost-effectiveness of wide scale provision of an intervention based on incremental patient costs (intervention costs at the point of delivery) at a single site with relatively developed infrastructure.
It is during this period that policy and decision makers may require additional intelligence due to the lack of real-time insight into wide scale social reaction following an event based on reported crimes.
A profound difficulty in a phenotype based assessment of epistasis on a genome wide scale is the need to correct for a huge number of tests with obvious consequences for statistical power.
To the network architect the creation process is ad hoc in nature, based on hand crafting small-scale network prototypes that evolve toward wide scale deployment.
Conservation on a wide scale takes more than good ideas.
"Wall-E" has not opened on a wide scale internationally.
He has already signalled he anticipates wide scale change.
