The need for improvement in the delivery of important care processes in ICUs has been demonstrated internationally [1 3], highlighting a gap between evidence and practice on a wide scale [4].
Unlike H3K9me3 and H3K27me3, which have been associated with repression of specific loci on a genome wide scale, H4K20me3 showed no obvious association with active or repressed promoters [50].
Europe has not yet been confronted with CA-MRSA on a wide scale 23 contrary to Canada and the USA where high prevalences are found.
Beyond general assessment papers [2, 3, 4, 5, 6, 7], several authors focused their attention either on particular corridors/areas [8, 9, 10, 11] or on a wider scale [12, 13, 14, 15, 16, 17].
The ocean component incorporates a simple biogeochemical process: Nitrogen-Phytoplankton-Zooplankton-Detritus, which reasonably simulates the seasonal excursion of oceanic biological activities at a basin-wide scale [19].
All those reality of the condition limits cost-effective utilization of natural gas via syngas process on a world-wide scale [7].
We assessed vulnerability in relation to (a) direct threats in and around sites to a distance of 2 km associated with intensive agriculture, building and road infrastructure and (b) indirect effects of human population density on a wider scale (50 km).
First, we re-analyzed the biologic data from investigations of genome-wide scale [1], [24], using a bioinformatics program called DAVID [25] and grouped miRNA regulated genes into functional annotation clusters.
Moreover, the establishment of protein labeling methods has enabled the quantitative measurement of proteins and peptides in samples on a proteome-wide scale [5], [6].
On a genome-wide scale p53 phosphorylated at S46 DNA-binding does not predict the occurrence or magnitude of expression change of the respective target genes.
Using a combination of gel-based and gel-free proteomics the final destination and fate of each single protein can be followed at a proteome-wide scale [13].
