There are some strong points of our study including face-to-face assessment of headaches by a specifically trained physician group with electronic database system, a large nation-wide sample size and a random population, strict application of the ICHD-II diagnostic criteria of the IHS excluding the subjectivity of the physician's diagnosis.
A larger or wider sample size would be needed to confirm this.
The high sensitivity and reproducibility of this new diagnostic algorithm strongly support a further validation on a wider sample size.
However, the high sensitivity and reproducibility of this new diagnostic algorithm strongly support a further validation effort on a wider sample size, to investigate whether this potential tool could become a part of the routine diagnostic procedure.
Moreover, further replication studies using a wider sample size and different population would be essential for further evaluation of the relationship between the CXCL12 genetic variations and the risk of asthma.
Although the ranges of values for the covariates tested were wide, the sample size was very small.
But the confidence intervals were not that wide, therefore sample size is adequate for the interpretation of results.
Data provided by group 1 provided preliminary data (wide variation/small sample size) that compared subjects with severe shoulder impingement to age-matched controls with no shoulder pathologies.
This is dependent upon the number of simulations (especially construction-wide assessment), sample size, number of SNPs considered and threshold values.
Moreover, the wide variations in sample size, selection of participants (usually non-random), and study design reported in the reviewed studies have compounded this situation further.
First, the age range of the obese and lean participants in this study is wide and the sample size is small.
