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A wide range of variant annotations can be used for filtering call sets in order to improve the precision of the variant calls, but the choice of the appropriate filtering thresholds is not straightforward.
Future development programs of individualized cancer immunotherapy include analysis of a wide range of variant antigens observed in each cancer, such as mutant proteins associated with point mutation, translocation, and splicing variant, for the production of cancer vaccines or effector cell therapy that can attack variant neo‐antigens unique to each patient.
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WHEN Ford launched the new edition of its Mustang car earlier this year, it promised to offer a wide range of variants on the basic model.
That way, a wide range of variants of possible system concepts is restricted implicitly.
The decision to use a volunteer siting process requires maximum flexibility of the repository concept to allow it to be adapted to potential sites and hence a wide range of variants of the basic H12 repository design has been developed.
The growing number and increased coupling of functionality in embedded control systems, e.g. in the automotive domain, leads to complex networks of interacting features and a wide range of variants.
MutationTaster uses Bayesian methodologies to predict the relevance of a wide range of variants [ 69].
VarSim simulates and validates a wide range of variants, including single nucleotide variants, small indels and large structural variants.
The ability to recognize a wide range of variants should also improve mapping accuracy by recognizing the correct genomic origin of variant reads.
Such efforts could help develop influenza vaccines that protect against a wider range of variants and establish a more fundamental molecular basis for influenza surveillance (25).
In particular, the use of 1000 Genomes data provides an opportunity to examine the distribution of a wider range of variants in detail not possible using GWAS genotyping alone.
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