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Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70 91%).
High throughput screening (HTS) programs have demonstrated that the Vitamin D receptor (VDR) is activated and/or antagonized by a wide range of structurally diverse chemicals.
Conjugation of a wide range of structurally different amines including the amines with enhanced biological activity were studied in detail.
Results from the Tox21 curve-fitting analysis suggest that the human VDR is activated and/or antagonized by a wide range of structurally diverse chemicals including naturally occurring, synthetic, and environmental chemicals.
Identifying hits for a new target usually involves screening of a wide range of structurally diverse small molecules in an in vitro bioassay.
Since the BCRP effluxes a wide range of structurally diverse xenobiotic compounds from cells [12], the broad distribution of BCRP not only renders less complete distribution of drugs but also causes a poor response of cells to chemotherapeutics [13 15].
Similar(33)
These transporters are proposed to actively extrude or compartmentalize a wide range of chemically and structurally disparate drugs and other xenobiotics, thus providing protection from these compounds.
During method development, a wide range of chromatographic conditions and structurally related positional isomer probe molecules were exploited in an effort to gain insight into the specifics of the separation mechanism.
These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs, and most possess 12 alpha-helical transmembrane regions.
Second, aptamers are structurally stable across a wide range of temperature and storage conditions, maintaining the ability to form their unique tertiary structures.
The VAO/PCMH flavoprotein family consists of structurally homologous flavin-dependent enzymes that catalyze a wide range of chemical reactions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com