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ES cells must be capable of self-renewal while simultaneously retaining the capacity to commit to a wide range of differentiation lineages.
This suggests that these compounds might be effective against tumor types arising from a wide range of differentiation states.
These cells exhibited a wide range of differentiation potential with robust generation of granulocytes and functional macrophages and, to a lower extent, erythrocytes and megakaryocytes.
Indeed, the rigid timescale of differentiation and division is the key for generating staging patterns because a wide range of differentiation and division time creates asynchronous cohorts of germ cells and disrupts stages.
Growing stem cells as spheres has been the initial step in a wide range of differentiation studies, as well as studies in pharmacogenetics, teratogenesis and tumourigenesis [ 32, 34- 42].
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NETs, however, have a wide range of cellular differentiation.
Compared with mammals, fishes exhibit a striking plasticity in the sex determination process, and show a wide range of gonad differentiation mechanisms, such as hermaphroditism and gonochorism.
TBX1, which encodes a T-box-containing transcription factor that belongs to a large family of transcription factors, has distinct roles in a wide range of embryonic differentiation or response pathways.
PGA scaffolds, with their advantages of a suitable spatial structure and excellent biodegradability and biocompatibility, have been applied in a wide range of cell differentiation and tissue repair protocols [ 32, 33].
Our analysis methods are applicable to a wide range of stem cell differentiation models.
These proteins mediate a wide range of immuno-stimulatory, differentiation and proliferative responses of immune cells and are key effector outputs from activated lymphocytes [ 51].
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