To this end, in many studies a wide range of agents have been used.
There is a strong rationale to support the idea that drug-eluting fibers can be designed to realize multiple design constraints in a single product for topical HIV prevention: fibers are able to deliver a wide range of agents, incorporate multiple agents via composites, and facilitate controlled release over relevant time frames for pericoital and sustained (coitally-independent) use.
c-fos is kept silent in most cell types but is robustly induced by a wide range of agents [2] including: mitogens [3], cellular stresses such as UV irradiation [4] and mechanical stretch [5], synaptic stimulation [6], and lymphocyte activation [7].
These genes not only show a consistent up-regulation in in vivo pulmonary inflammation studies, but also a clear overlap with genes found to be induced in vitro [1] [4] (Supporting Dataset S1), corroborating the pivotal role these genes play in response to a wide range of agents.
Despite the wide range of agents considered, the group came to develop and adopt a common analytical framework that is based on mode-of-action concepts.
Bacteria of the genus Bartonella are susceptible to a wide range of agents, including penicillins, cephalosporins, aminoglycosides, chloramphenicol, tetracyclines, macrolides, rifampin, fluoroquinolones, and cotrimoxazole (40 ).
Central nervous system (CNS) infections pose a diagnostic challenge because clinical manifestations are not typically pathognomonic for specific pathogens, and a wide range of agents can be causative.
Hence, exposure to a wide range of agents could potentially lead to a limited spectrum of cross-resistance by downregulating expression of some specific transporters, and decitabine could potentially increase expression of some transporters, but not others.
A wide range of agents, including passive smoking [ 35] and occupational exposures [ 36] have been found to increase the risk of adverse pregnancy outcomes, and insufficient control of other environmental risk factors could have influenced the observed associations.
