(The nutrient has such a wide ranging effect, says Dr. Cannell, because it targets more than 2,000 genes -- 10percentt of the human genome).
Our data suggest that EGCG exerts a wide ranging effect on the expression of proteins associated with OA pathogenesis and correlated with the inhibition of NF-κB and MAPKs in human OA chondrocytes.
Peptides released at the CI tract region thus appear well suited to modulate interneurons, which in principle could provide an effective means to achieve wide ranging effects on different (interlinked) neuronal networks [114].
In an increasingly complex and interdependent society, emergencies can have increasingly multifaceted and wide ranging effects.
Prior research has shown that the physical characteristics of one's environment have wide ranging effects on affect and cognition.
Celiac disease is a chronic inflammatory condition with wide ranging effects on individual's lives caused by a combination of symptoms and the burden of adhering to a gluten-free diet (GFD).
The oceans are a major sink for anthropogenic atmospheric carbon dioxide, and the uptake causes changes to the marine carbonate system and has wide ranging effects on flora and fauna.
However, localized tissue renin-angiotensin systems (RAS) have been identified suggesting that Ang II may have wide ranging effects in addition to its systemic role in vasoregulation.
Furthermore, recent experimental and quantitative modeling work in the development of tooth cusps supports the notion that small genetic changes may have wide ranging effects on tooth cusp morphology [50], [51], [52].
For the approximately 100 OA-containing neurons found in the Drosophila nervous system, wide ranging effects on behavior have been reported, including actions on ovulation, aggression, sleep, and learning and memory [20], [21], [22], [23], [24], [25], [26].
Steroid hormones have wide ranging effects on the structure and function of the nervous system.
