10.7554/eLife.04094.011 Figure 4. Genome wide modeling of the methylation levels combining CG density prediction and DNase hypersensitivity data.
System-wide models of upper trophic levels in the GoMA suggest that an important component of fish biomass remains unquantified [15][16].
While cell-wide, or organism-wide, models of genetic and molecular interactions appear well out of reach, predictive models of single pathways and small modular molecular networks of living cells have been studied with great success and are a matter of active research [1] [4].
We use these collections to build genome-wide models of thousands of defined phenotypes in both model species.
Ambitious national and international research projects such as the Virtual Liver Network [ 2] strive to derive even organ-wide models of biological systems that include all kinds of processes taking place at several levels of detail.
Based on systems-wide models of the industrial microorganisms Corynebacterium glutamicum and Aspergillus niger, up to more than 20,000 modes were obtained for each case, differing strongly in production performance and intracellular fluxes.
The data and analyses reported here contribute to both these activities, and they should be considered as part of a larger effort to build genome-wide models of gene regulation that incorporate information about chromosomal position and cell context.
We address these questions with a system-wide model of E. coli proteostasis.
In other words, cultural (a preferable term to civilisational) aspects shape societies' worldviews, but culture is not an impermeable barrier to a wider model of order that can bring different regimes together.
The displays include a restored, 12-minute, seven-screen version of THINK, the Eames film shown inside the egg-shaped section of the IBM Pavilion, as well as a reconstruction of a nearly 10-foot-wide model of that building.
