Here, we highlight three areas where genome-wide methods can add to the understanding of genetic architecture.
García-Martínez, J., Pelechano, V. & Pérez-Ortín, J. E. Genomic-wide methods to evaluate transcription rates in Yeast.
We are using genome-wide methods, ChIP-seq, to find locations that THAP9 binds in the human genome.
In particular, we concentrate on recent studies using genome-wide methods, single-molecule technologies, and super-resolution microscopy (SRM).
Current Research and Scholarly InterestsOur laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers.
To address these questions, we have developed new genetic and molecular reagents in yeast including novel genome-wide methods to map the position of hybrids and the regions of DNA damage that are associated with a subset of hybrids.
The Network will continue to develop 3C-based technologies, including genome-wide methods that enable the exploration of higher-order (beyond pairwise) DNA contacts, detection of chromatin interactions in (thousands of) individual cells36, and mapping of RNA DNA interactions (Table 2).
Here we discuss how proteomics-based approaches provide a set of viable methodologies capable of delivering quantitative information throughout the main stages of personalised oncology and a ratiometric platform that delivers systems-wide methods for drug evaluation.
Genome-wide methods, including fixed arrays and next generation sequencing, provide marker densities appropriate for genome-wide association studies, QTL mapping, diversity analysis, DNA fingerprinting, impact assessment studies, and breeding applications such as genomic selection (Thomson 2014; Varshney et al. 2014).
For this reason we strongly recommend that additional genome-wide methods to characterize polymorphisms [17], re-sequencing of probe regions, and alternative ways of gene expression profiling are employed whenever strong claims about cis eQTLs are to be made.
