We took three approaches to investigate further whether the genes predicted to be regulated by E2F genes in Clusters 8, 32 and 34 are validated in classical non-genome wide methods.
The mass release of sterile insects (the Sterile Insect Technique, SIT) is a highly effective area-wide method of pest control with a low environmental impact.
We hypothesized that we could use a genome-wide method for assessing laboratory selections to design selections with enhanced sensitivity (true positives) and specificity (true negatives) towards a single desired phenotype.
The ability to utilize both pH and temperature as selectivity variables allows the chromatographer to exploit a much wider method development design space including previously prohibited alkaline conditions.
Thus, we only try to compare drugCIPHER with a currently available non-genome-wide method, the BLM [11], which is also the most precise model for target prediction.
We used the gene expression of each of these transcripts as a phenotype, along with a high density genome scan composed of 1,967 informative SNPs on a mouse SNP chip [15], to identify eQTLs associated with the expression level of each transcript in a genome-wide method of generating LOD plots for expression of each transcript across the mouse genome.
Therefore, a genome-wide method to directly quantify differences in RE cleavage would be highly desirable in these assays.
The development of microarray analyses represents a genome-wide method for measuring differences across strains, focusing on expression differences.
In this study, we developed a unique genome-wide method to discover DNA motifs associated with chromatin accessibility.
It is also important to note that, since target selection is part of the procedure, these methods do not represent a genome-wide method.
The development of microarray analyses represents an additional genome-wide method for measuring differences across strains, focusing on expression differences rather than on sequence differences in the genome.
