Exact(3)
Kink bands develop extremely progressively, leading to the formation of a wide localization zone (or FPZ, failure process zone).
Taking advantage of previously published genome wide localization maps of transcription factors involved in ES cell biology (28), we examined the promoter regions of lncRNAs for the presence of transcription factors.
We are not certain to which paper the reviewer is referring to, but we suspect it to be the recent paper by the Andrews group concerning the proteome wide localization analysis (Chong et al. 2015).
Similar(57)
Chromatin immunoprecipitation coupled with microarray analysis (ChIP-Chip) has become a widely used method for genome-wide localization of protein-DNA interactions [ 1].
In agreement with genome-wide localization studies [10] and recent in vitro transcription assays [19], we found an important role for Mediator in activation.
Additionally, methylation of histone H3 at lysine 122 has recently been reported in mice [93], and genome-wide localization patterns of methylation of lysine 5 on histone H2B have been reported in humans [41], [42].
Thousands of Ctcf binding sites have been identified in recent genome-wide localization studies, and their distribution along the genome further supports a crucial role of Ctcf as a chromatin organizer [38] [41].
The only GO annotation available for Yer067w comes from a genome-wide localization study using GFP-tagged proteins and points to a nuclear and cytoplasmic localization for Yer067w during normal growth conditions [15].
Transcriptional factor (TF) binding sites can be localized to regions other than the 5' proximal promoter regions, such as far upstream sequences, introns, and 3' of the gene as exemplified by genome-wide localization analysis (GWLA) of two transcription factors (p53 and estrogen receptor) [35], [36].
Despite this close correlation in genome-wide localization, a functional relationship between H4K10Ac modification and ORC1/CDC6 recruitment seems unlikely.
Subsequent ChIP followed by next-generation sequencing (ChIP-seq) was used to map the genome-wide localization of the analyzed histone variants and define their chromatin domains.
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