Circular chromosome conformation capture, when coupled with next-generation sequencing (4C-Seq), can be used to identify genome-wide interaction of a given locus (a "bait" sequence) with all of its interacting partners.
Elucidation of system-wide interaction of molecular and signaling events and comparison with the response of pathological cells under the influence of a therapeutic drug provide new quantitative mechanistic insights.
These 22 questions were put together by the authors following wide interaction with referring physicians of various specialties from different countries.
However, wider interactions of those networks are comparatively less well understood.
By combining advanced omics technology and computational modeling, systems biologists have identified and inferred thousands of regulatory events and system-wide interactions of the bacterium Bacillus subtilis, which is commonly used both in the laboratory and in industry.
Here, we discuss how distinct genome-wide interactions of RBf2 point to possible diversification in functions for these RBf proteins.
We also used this novel approach to elucidate differential genome-wide interactions of two central amino acid metabolic networks, namely the Asp-family and AAA metabolic networks,.
A comparative analysis to map genome-wide interactions of gene promoters with lamin A and Progerin indicates that lamin-A associates with transcription factors, and its variant Progerin induces global changes in chromatin organization by enhancing interactions with a specific subset of genes in addition to defined lamin A associated genes [ 16].
Here, we have used an unbiased approach to comparatively map genome-wide interactions of gene promoters with lamin A and progerin, the mutated lamin A isoform responsible for the premature aging disorder Hutchinson Gilford progeria syndrome (HGPS) in mouse cardiac myoytes and embryonic fibroblasts.
The most recent Hi-C data analysis has used a new algorithm and provided a genome-wide interaction map of 10 kbp resolution.
This technology was used to map genome-wide interaction sites of three different lncRNAs including HOTAIR, and has revealed focal, sequence-specific binding at numerous sites in the genome [67].
