During stress adaptation when gene regulation activity is highly elevated, two clearly distinct genome-wide functions of the Gcn5 HAT are revealed.
These benefits would be lost if the wider functions of the exercise ECG were not implemented through other means once the exercise ECG is phased out of the assessment of patients with new onset stable chest pain in line with the UK NICE chest pain guidelines.
The wider function of the rmPFC in humans may be to integrate value across time and assets, potentially to calculate the value of prospective states or investments.
They also exert much wider functions outside of the vasculature such as regulation of lipid, glucose and energy metabolism (Hato et al., 2008), inflammation (Tabata et al., 2009), and cancer (Zhu et al., 2011).
In order to study the wider functions of Dsg3 we cloned full length human Dsg3 and over-expressed this gene in various epithelial cell lines, including the A431 epidermoid line.
These two contradictory bodies of evidence imply the wider function of AhR in the presence and absence of a ligand.
The genome-wide function of cohesin complexes in the organization of chromosomal architecture described here suggests that the effect of cohesin loss on gene regulation may be profound, albeit indirect.
The reason was believed to be wider autocorrelation functions of the latter ones.
Thus, addressing the underlying disease mechanisms not only contributes to our understanding on the organism-wide function of Cdc48 but also facilitates the design of specific medical therapies.
In the future, it will be interesting to investigate how the genome-wide function of MSL and NSL changes during distinct mESC differentiation pathways.
To gain more insights into the genome-wide function of Tip60 in mESCs, we have generated high quality ChIP-seq data using previously characterized purified polyclonal anti-Tip60 antibodies that specifically recognize endogenous Tip60 [ 20].
