Currently, we do not have a standard guideline to report genome-wide experiments in functional context.
So it has become like a giant world-wide experiment in practical evolution.
Finally, we present the conclusions of this community-wide experiment in systems biology modeling.
Neither study identified p38 or MK2 as having increased levels, demonstrating that kinase activity measurements can provide valuable insight into cellular signaling that would not have been otherwise observed in genome/proteome wide experiments.
Importantly, in the genome wide experiments neither VDR, CYP24A1 nor other known vitamin D signaling pathway genes were associated with 1,25D resistance.
When there were UK-wide experiments with double summer time in the 1970s, Scottish pupils had to go to school in the dark.
We found many more putative binding sites than have been previously identified in genome-wide experiments for p53/p63/p73 proteins [ 44- 46].
As 'gene' has become a vague definition and new 'genon' concept been proposed [22], the work presented here might bring about the initiative to come up with a standard functional format in reporting genome-wide experiments for future systematic integration.
When comparing our transcriptomic data with the results from other genome-wide expression experiments in L. monocytogenes, we noticed an overlap with genes identified as belonging to the σB regulon [12], [33].
One characteristic of condensin I and II complexes that recently emerged from genome-wide mapping experiments in budding and fission yeasts, C. elegans, chicken DT40 cells, and mouse embryonic stem cells is that both complexes are enriched at promoters of active genes (D'Ambrosio et al. 2008; Dowen et al. 2013; Kim et al. 2013; Kranz et al. 2013).
Such strategies would find broad application in genome-wide experiments and large-scale research efforts such as the development of multigenic disease models.
