Another interesting finding is the similarity between the patterns of evolutionary conservation of CS and cancer genes, which suggests the co-evolution of these two phenomena and calls for a wide comparative study.
In contrast, genome-wide comparative studies of steady-state systems showed that only a small fraction of active enhancers are conserved.
By using these two well-assembled genomes, we performed genome-wide comparative studies that unraveled the genomic components responsible for contrasting features between the species, demonstrating their origin in homeolog losses, genome restructuring in the postpolyploidization era and altered patterns of gene expression.
With the increasing number of sequenced genomes, many genome-wide comparative studies have emerged to explore this topic [1], [2], [3], [4], [5], [6], [7], [8], [9], [10].
However, genome-wide comparative studies of mammalian promoters suggested an accelerated evolution of primate promoters during the last 25 million years [ 8- 10].
In order to overcome the lack of thoroughness and inclusiveness that candidate gene approach is criticized for, we conducted the genome-wide comparative studies on common form of obesity traits.
Genome-wide comparative studies can be effectively used to identify genes and regulatory patterns that are constrained to preserve core functions from those that may help to account for the diversity of animal reproductive strategies.
Understanding of not only the classification but also the evolution of species in the East Asia Clade is greatly weakened by the fact that there has been no group-wide comparative study of the morphology of living plants to compare with our present survey of the corresponding DNA regions.
Although these factors have potential limitation to any genome-wide comparative study, it is unlikely that these limitations have any effect on the results of our current study.
