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From the results of this investigation the following factors were found significantly more frequently in pSM2-3 lesions compared to pM-pSM1 lesions (P < 0.001): wide caliber, irregular caliber, tortuousity, irregularity, short length and non-dense arrangement.
Cranial MRI displayed brainstem infarction and computer angiography revealed a giant basilar artery aneurysm, which was not the typical spindle shape, with wide caliber in the proximal centre and more slender at the extremities.
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These capillaries are tortuous and of wider caliber.
We have previously reported that wider arteriolar caliber is associated with an increased risk of diabetic retinopathy in both type 1 and type 2 diabetes (3, 23).
Thus, the finding of an association of higher blood pressure levels with increasing arteriolar LDR (reflecting wider arteriolar caliber) is consistent with the influence of diabetes and blood pressure on autoregulatory processes in small blood vessels.
A study of a multiethnic Asian population with diabetes showed that wider arteriolar caliber, but not venular caliber, was independently and cross-sectionally associated with peripheral neuropathy as defined from neurothesiometer or monofilament sensory testing (multivariable adjusted odds ratio [OR] 2.81 [95% CI 1.38 5.73]) (32).
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However, longer diabetes duration was associated with wider vessel calibers (both arteriolar and venular).
Lower LDR can result from shorter axial length due to earlier branching points or wider vessel calibers, or both.
As previously described, lower LDR can result from shorter axial length due to earlier branching points and/or wider vessel calibers (14).
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