We demonstrated that treatment with EEDS up- or down-regulates diverse genes that are closely associated with numerous genome-wide biological functions [ 6].
A wide variety of biological functions are captured, reflected by the wide range of GO annotations, from low abundance proteins involved in transcription, to very high abundance proteins, such as histones and factors involved in ribosome subunit assembly.
NF-κB is a widely expressed molecule with a wide range of biological functions including a role in regulating inflammation [ 29], cell differentiation, apoptosis and cell proliferation [ 30].
Co-expression analysis indicated significant enrichment of the CBSGs and ALSGs in multiple functional categories suggesting their involvement in a wide range of biological functions.
Thrombospondin-1 (TSP-1) is a homotrimeric glycoprotein which modulates a wide range of biological functions.
Light exerts powerful non-visual effects on a wide range of biological functions and behavior.
Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions.
The wide spectrum of biological functions of GHS-R1a has rendered it a target for therapeutic drugs and for molecular imaging agents, for a variety of diseases.
Vasoactive intestinal peptide (VIP) is one of the major peptide transmitters in the central and peripheral nervous systems, being involved in a wide range of biological functions.
The platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF, PVF) family of proteins have been implicated in a wide range of biological functions in vertebrates, including cell proliferation, cell differentiation, cell migration, neural development and especially angiogenesis/vasculogenesis.
DNA methylation is an important epigenetic modification that leads to a wide variety of biological functions, including transcription, growth and development, and diseases associated with altered gene expression such as cancers.
