Sentence examples for wide alterations from inspiring English sources

Since we previously showed that the lack of muscle contractions leads to common phenotypic defects in both ossification and joint formation in several chick and mouse models, this provides an insight into the genome wide alterations in gene transcription that take place when the mechanical environment is altered.

Jackson and Loeb [ 31] estimated ~100,000 genome wide alterations in cancers in the form of base substitutions, deletions, chromosomal translocations, and gene amplifications, and these mutations are found to accumulate as tumors progress.

We also identified changes in multiple other ether lipid species including phosphatidylcholine-plasmalogen (PCp), phosphatidylinositol-ether (PIe), and phosphatidylglycerol-ether (PGe), likely due to network wide alterations stemming from 2-acetyl MAGe or MAGe metabolism.

These centers are surrounded by 10 20 m wide alteration haloes of oxidized and sintered oxidized mudstone and an outer fringe of coked organic matter.

Of note, while mitochondria dysfunction is present in PGC-1β KO neurons under non‐stimulated basal conditions, this is not associated with a wide alteration in lipid species composition including ER stress precursor ceramides.

Since PARP inhibitors are shown to cause hypermethylation of particular genes [ 13], loss of Parp-1 may possibly cause local changes in DNA methylation pattern during DNA replication and may further affect histone acetylation or methylation, thereby causing genome wide alteration of gene expression after rounds of cell division.

Although alterations of DNA methylation are considered to be involved even in the precancerous stage in various organs (6, 7, 33– 35), it has not yet been clarified for any organ whether DNA methylation status on only a restricted number of CpG islands is simply altered at such stages or whether genome-wide alterations of DNA methylation status have certain clinicopathological significance.

1) To describe genome-wide alterations in micro RNA (miRNA) expression following severe trauma.

We conducted transcriptome analysis to evaluate the genome-wide alterations and their relation with pollen sterility in autotetraploid rice hybrids during meiosis.

Contributing methylation loci were both gene associated loci (30%) and non-gene associated (70%), suggesting subtype dependant genome-wide alterations in the methylation landscape.

To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations.