Sentence examples for wide alteration from inspiring English sources

These centers are surrounded by 10 20 m wide alteration haloes of oxidized and sintered oxidized mudstone and an outer fringe of coked organic matter.

Of note, while mitochondria dysfunction is present in PGC-1β KO neurons under non‐stimulated basal conditions, this is not associated with a wide alteration in lipid species composition including ER stress precursor ceramides.

Since PARP inhibitors are shown to cause hypermethylation of particular genes [ 13], loss of Parp-1 may possibly cause local changes in DNA methylation pattern during DNA replication and may further affect histone acetylation or methylation, thereby causing genome wide alteration of gene expression after rounds of cell division.

Since we previously showed that the lack of muscle contractions leads to common phenotypic defects in both ossification and joint formation in several chick and mouse models, this provides an insight into the genome wide alterations in gene transcription that take place when the mechanical environment is altered.

Jackson and Loeb [ 31] estimated ~100,000 genome wide alterations in cancers in the form of base substitutions, deletions, chromosomal translocations, and gene amplifications, and these mutations are found to accumulate as tumors progress.

We also identified changes in multiple other ether lipid species including phosphatidylcholine-plasmalogen (PCp), phosphatidylinositol-ether (PIe), and phosphatidylglycerol-ether (PGe), likely due to network wide alterations stemming from 2-acetyl MAGe or MAGe metabolism.

Genome-wide alteration in methylation is extensively found with age.

Moreover, 30 of the 55 tumors (54.5%) had genome-wide alteration fractions higher than 0.5 (Table S6), suggesting severe genomic instability in those ESCC samples.

These findings suggested that PML RAR α expression has the potential to confer a genome-wide alteration in epigenetic make-up.

In this study, we demonstrated that burn-elicited stress signals were responsible for a differential genome-wide alteration in MuERV expression in a tissue- and U3 promoter-specific manner.

Meanwhile, a recent study indicates that telomere DNA is transcribed to a non-coding RNA called TERRA, which is implicated in genome-wide alteration of gene expression in human cancer cells in vivo (Hirashima and Seimiya, 2015).