On the basis of work with polyamides and heterocyclic diamidines, such as DB293, dimer-forming compounds have been used to enhance specificity and affinity for wider DNA minor grooves with GC base pairs.
DHE displays affinity for a wide variety of receptors [1], with the same nanomolar affinity for rat α1-adrenoceptors (pKi: 8.0) and rat α2-adrenoceptors (pKi: 8.0) [7].
To improve upon this, our colleagues have identified a short peptide sequence using a phage display library with a high affinity for a wide range of bladder cancer cells across multiple species including mouse, dog, and human, and with little affinity for normal bladder epithelia.
BLIP is a 165 amino acid protein that inhibits several class A β-lactamases with a wide range of affinities: picomolar affinity for K1; nanomolar affinity for TEM-1, SME-1, and BlaI; but only micromolar affinity for SHV-1 β-lactamase.
Both ergotamine and dihydroergotamine (DHE) share structural similarities with serotonin, dopamine and (nor)adrenaline, and have been shown: (i) to display affinity for a wide variety of receptors including serotonin 5-HT1/2, dopamine D2-like and α1/α2-adrenoceptors [1]; and (ii) to be effective in the acute treatment of migraine [2].
Human serum albumin is a major extracellular protein with high affinity for a wide range of metabolites and drugs [17] [25] and its abundance is high in the blood plasma (40 mg ml−1) [27], [27].
Indeed, the NMR-refined free DNA structures revealed that BII-rich phosphates favor wide minor grooves, promoting the affinity for DNase I and thus the DNase I cleavage efficiency [13].
Their affinity for a wide range of metal ions makes them ideal metal chelators in the formulation of therapeutic and diagnostic metallopharmaceuticals.
He's a skinny white rapper with an affinity for denim, wide-brimmed hats, and tattoos, one of which is inked across his hairline and reads slumerican, a word he coined as a way of trying to reclaim terms like "white trash".
This week we're channeling Duvall's Millie Lammoreaux, a wide-eyed, chatty, ditzy loner with an affinity for rust-colored makeup, super 70s bobbed hair and a deep tan.
