Sentence examples similar to wide aberrations from inspiring English sources

Genome-wide aberrations of the classic epigenetic modification 5-methylcytosine (5mC), considered the hallmark of gene silencing, has been implicated to play a pivotal role in mediating carcinogenic transformation of healthy cells.

In initial CGH (Agilent 244k) experiments we observed that in LAU-Me275, and other highly hyperploid cell lines, the hybridization ratios between cancer cells and matched controls did not reflect the chromosome-wide aberrations observed in the karyotypes.

Another advantage of CLImAT lies in the fact that it takes integrated analysis of RD and BAF using a novel HMM to provide accurate detection of genome-wide aberrations in tumor samples.

These lung carcinogens can induce a wide range of molecular alterations, including genetic (from specific point mutations to genome-wide aberrations) and epigenetic (including alterations in DNA methylation, and microRNA expression) [ 25].

The method we chose to examined genome wide chromosomal aberrations is a published and publically available method to look for recurrent copy number alterations and differential copy number alteration[ 31].

A well established screening method to detect the genetic changes that underlie carcinogenesis is comparative genomic hybridization and was first introduced by Kallionemi and colleagues in 1992 [ 32] In the present study we examine genome wide chromosomal aberrations in primary CRC to identify molecular markers predictive for liver metastases.

We used cDNA microarray based-CGH to investigate the genome-wide genetic aberrations of thymoma.

Digital karyotyping was an effective method for analyzing genome-wide chromosomal aberrations at high resolution.

Genomic DNA (500 ng) was used as the starting material to capture genome-wide chromosomal aberrations with the aid of the Affymetrix Genome-Wide Human SNP 6.0 array technology.

Here, we investigated genome-wide chromosomal aberrations in defined groups of primary colorectal tumors to determine copy number signatures for site specific metastases.

Microarray-CGH experiments were performed with the indirect design to determine the genome-wide genetic aberrations in thymoma subtypes using sex-matched placental tissue as a reference.