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How long and why this defect persists merits further investigation through follow-up studies.
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It remains unsolved why this described defect in HR leads to the tissue-specific cancers of the breast and ovary.
ITR USA of Woodland Hills, Calif., said it was not certain why the defect occurred and was not aware of any accidents.
When we "ask five times why," the defect opens a window onto the functioning of the system.
To strengthen their hypothesis, the authors need a more mechanistic explanation why the defect of RING domain loss appeared only in the Tfh program.
Discussing this observation, Mann and colleagues proposed two scenarios to explain why the defects were apparently restricted to the trophectoderm lineage [ 69 ].
The existence of such mechanisms may explain why the defects in brain size and cellularity are more severe in Dyrk1a+/− mice than in mBACtg Dyrk1a mice.
There are several possible explanations for why these defects might arise, including abnormalities in cell proliferation or death, cell migration into the heart, and interactions between cardiomyocytes and maturation of the ventricle.
Why this should have been such a defect was not entirely clear to us at the time.
The Commission corrected this defect.
The two secretins, yheF and hofQ, from CFT073 may perform overlapping or redundant functions, explaining why a defect was only detected in the double knockout strain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com