Sentence examples for whose sumoylation is required from inspiring English sources

In addition, NO has been shown to desumoylate DJ-1 in neural cells, whose sumoylation is required for the full protective functions of DJ-1 (unpublished observation).

The sumoylation-deficient mutant of HDAC1 also shows lower deacetylase activity [37], [48], suggesting that sumoylation is required for the full activation of the catalytic activity of HDAC1.

We are able to detect transcriptional coactivator effects of ectopic lipin-1α in neuronal cells, and show that sumoylation is required for this activity, consistent with the effects of sumoylation on the nuclear localization of lipin-1α.

Hence, if sumoylation is required to bring CBS (and potentially, CSE) into the nucleus, desumoylation of nuclear CBS would be needed for the enzyme to be active.

In addition to PCNA monoubiquitination, Siz1-mediated PCNA sumoylation is required for TLS stimulation.

10.7554/eLife.08009.005 Figure 2. Transactivation but not sumoylation is required for LXR-mediated inflammatory repression.

To test whether SUMOylation is required for TBX-2 repression, we examined the effect of inhibiting SUMOylation on tbx-2:: gfp expression.

SOP-2 sumoylation is required for in vivo localization to nuclear bodies and repression of HOX genes [ 30].

This is in striking contrast to the SSA results and suggests that Saw1 sumoylation is required for its role in UV condition.

We next tested whether RIM1α SUMOylation is required for normal presynaptic Ca2+ signaling, using a presynaptically targeted Ca2+-sensitive GFP reporter (SyGCaMP3) (Li et al., 2011).

Sumoylation of HDAC1 is required for its function in transcriptional repression [37], [48].