Sentence examples for whose specificity from inspiring English sources
Unlike other site-specific endonucleases whose specificity resides within a protein, the specificity of Cas9-mediated DNA cleavage is determined by a guide RNA (gRNA) containing an ∼20 nucleotide locus-specific RNA sequence, representing a major advance for versatile site-specific cleavage of the genome without protein engineering.
Total RNA was isolated as described in [ 20] and cDNA synthesis and RT-PCR performed in the linear phase of amplification according to [ 11] and [ 18] with gene specific primers, whose specificity was controlled by sequencing of the amplification products.
We subjectively defined characteristics whose sensitivity estimates were higher than their specificity estimates as "sensitive" tests, and characteristics whose specificity estimates were higher than their sensitivity estimates as "specific" tests.
Importantly, a TRPML1 agonist, whose specificity was confirmed with mouse knockouts, was shown to be cell permeable with reversible effects (Shen et al., 2012; Garrity et al., 2016).
As expected, a similar correlation was obtained for five standard mAbs whose specificity for either common or restricted epitopes of porcine CD45 had been established in previous workshops.
This paper presents a composite damage behavior law whose specificity is to take into account the variability of some material parameters.
In general, for each organism of interest, genes were chosen whose specificities included unique as well as conserved sequences.
In contrast, we utilized anti-UBQLN1 antibody sc-14652 and anti-UBQLN2 antibody sc-14658, whose specificities were individually validated by western blot analysis of the corresponding recombinant proteins expressed in HEK293 cells.
The lack of a diagnostic gold standard limits the ability to weigh the performance characteristics of metabolic biomarkers such as methylmalonic acid (MMA) and holotranscobalamin II, whose specificities remain incompletely defined outside their relations to each other.
Sequence elucidation and phylogenetic analysis of MT isoforms from a number of snail species revealed that they possess an unspecific and two metal-specific MT isoforms, whose metal specificity was achieved exclusively by evolutionary modulation of non-cysteine amino acid positions.
To help understand the determinants of TCR specificity, we studied a parental and engineered receptor whose peptide specificity had been switched via molecular evolution.
