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Here, we take a computational synthetic biology approach to tackle a somehow different and new problem: identifying sets of cellular factors whose perturbation results in the same transcriptomic pattern that is observed in plant cells infected by viruses.
It yields a simple analytic formula that gives the real and imaginary parts of the frequency in terms of the parameters of the black hole and of the field whose perturbation is under study, and in terms of the quantity (n + 1/2), where n = 0, 1, 2,... and labels the fundamental mode, first overtone mode, and so on.
Not long after, DNMT3A and DNMT3B were further implicated in both hematopoietic stem cell (HSC) renewal and differentiation, two tightly regulated processes whose perturbation can lead to carcinogenesis (Challen et al., 2012; Tadokoro et al., 2007).
Howland also discovered that even when (A_0) and B were self-adjoint, an eigenvalue could turn into a second order pole whose perturbation series could have non-trivial fractional power series in the asymptotic expression, i.e. Rellich's theorem fails for resonance energies.
We next systematically investigated the sensitivity of all the rate constants and found those whose perturbation the pathway is most sensitive or most robust against.
Thus, identification of chemicals that alter cell migration, or specific genes whose perturbation affects cell migration could potentially be used for the modulation of metastatic cell migration.
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These correlated motions include (but are not limited to) the side chain motions whose perturbations manifest as the dynamic conduit.
Table 2 shows the top ten reactions whose perturbations resulted in the largest reductions of inconsistencies (the complete list is provided in Additional file 3).
The motivation for investigating synthetic lethal targets was that there may be other drugs that act on multiple L. major targets whose simultaneous perturbation results in growth inhibition of the parasite.
During the late main phase of the April 6, 2000 storm with Dst approaching −300 nT, four Defense Meteorological Satellite Program (DMSP) satellites encountered repeated episodes of intense field-aligned currents whose magnetic perturbations exceeded 1300 nT, corresponding to |J∥| > 1 A/m.
Thus, the vector x is optimized for a worst case perturbation whose range is determined by the parameter λ, that is, the algorithm is robust to perturbations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com