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The versatility of CFP has been recently exploited to detect key enzymes whose malfunction is responsible for changes in metabolomic data [ 39].
In this work, we present a novel network-based framework to find candidate enzymes whose malfunction is responsible for the accumulation of a given metabolite.
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Genes with essential cellular functions would appear on the lower end of the functional impact score scale, while genes whose malfunction can be compensated for by diverse mechanisms or does not lead to very deleterious phenotypes are located at the upper end of the FIS scale.
This is the case with BRCA1 and BRCA2, two similar tumor suppressor genes whose malfunctioning has been linked with considerably increased risk for breast and ovarian cancer.
Dolichol functions as a free-radical scavenger in the cell membranes, and may interact with Vitamin E and polyunsaturated fatty acids to form a highly matched free-radical-transfer chain whose malfunctioning might be involved in statin toxicity.
A wardrobe malfunction is, quite frankly, inexcusable.
A malfunction is a central element in the Williams defense.
Wardrobe malfunction is fast approaching wardrobe crisis.
Assume a metabolite is identified in significantly high concentration and we are concerned with finding enzymes whose malfunction explains its accumulation.
The specific reaction whose malfunction returns a similar profile to the measured molecules is regarded as the malfunctioning reaction that leads to the abnormal profile shown in clinical data.
Cilia are structurally and functionally diverse organelles, whose malfunction leads to ciliopathies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com