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Analysis of the conditional null mutant in repressing and inducing conditions indicates that UBI3 is an essential gene whose expression is required for growth of C. albicans.
The PhoP regulon is a well studied two component (PhoP/Q) coordinately regulated network of genes whose expression is required for intracellular survival of S. enterica.
The aim of this study was to identify the genes within the 19q12 amplicon whose expression is required for the survival of cancer cells harbouring their amplification.
Our data suggest that miR-132 downregulates proteins whose expression is required for the fast-onset but short-duration memory pathways.
Arsenite reacts with oxygen, induces oxidative stress and then activates HRI (Heme-regulated inhibitor), whose expression is required for SG formation [ 21].
The model also predicts that TNF may promote T-cell effector responses indirectly by suppressing NFAT-dependent genes whose expression is required for immunoregulation and peripheral tolerance.
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The development of mature blood cells from haematopoietic precursors requires additional transcription factors and includes the ETS-family member PU.1 whose balanced expression is required for correct myeloid and lymphoid development (McKercher et al, 1996; Scott et al, 1997; Rosenbauer et al, 2006; Leddin et al, 2011).
siRNA silencing of all genes mapping to the 19q12 amplicon revealed the existence of genes other than CCNE1 whose expression is selectively required for the survival of cancer cells harbouring amplification of this locus.
The karyophilic Rev protein, whose expression is promoted by viral DNA, is required at the late phase of the viral replication cycle for promoting nuclear export of partially spliced or un-spliced viral RNA [23], [24].
kin- cells provide a means to identify proteins whose expression is PKA-dependent and does not require activation of Epac.
The TLR1/2 and TLR6/2 ligands, which resulted in cartilage collagen resorption, require TLR2, whose expression is significantly repressed in end-stage OA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com