The evidence for a dose-dependent relationship is strengthened by evidence from a case report of a palliative care patient whose urinary symptoms paralleled the use, discontinuation, reintroduction, and repeat discontinuation of analgesic ketamine (91).
All active smokers admitted with SAH were included in the analysis, but we excluded patients who died within 7 days of admission to remove those whose death was due to discontinuation of life support.
Of those patients whose opioid treatment was discontinued due to medication agreement violation-related discontinuation (MAVRD) (n = 38 or 28% of sample), 40% of these (n = 11) were due to specific problematic opioid misuse behaviors.
Even Monaghan, who's a vocal supporter of SSRIs when used correctly and whose SSRI of choice, paroxetine, has lower discontinuation rates according to Jern's study, warns against misuse.
This phenomenon was termed as "the paradox of indomethacin", whose most prominent side effect and reason for discontinuation (headache) is the very symptom for which it provides a remarkable therapeutic efficacy [31].
Treatment was definitively interrupted in patients whose AE did not resolve after 2 weeks of discontinuation or who required a second dose reduction.
However, 70% of patients with seizure recurrence after AED discontinuation reachieved remission, as opposed to 50% of those whose seizures recurred while reducing AEDs (P = 0.0001).
Patients whose disease had not progressed at the time of study treatment discontinuation continued to be assessed until progression was documented.
Liver biopsies were recommended but not required for patients whose liver-enzyme elevations did not normalize within 6 months of discontinuation from the study and were obtained at the investigators' discretion.
Patients with RA and patients with SpA whose infliximab treatment was started between December 2005 and January 2009 or until infliximab discontinuation were retrospectively included.
