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Burning coal, whether local or imported, generates large quantities of fly ash containing toxic pollutants like lead, zinc, arsenic, cadmium, sulfur, mercury and radioactive uranium/ thorium isotopes, which adversely affect the health of the people near the power stations, often the rural poor, whose disadvantage is worsened by these health impacts.
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Lamivudine and adefovir are early-generation oral agents whose main disadvantage is the high viral resistance they engender.
Disadvantage is ubiquitous.
But a further disadvantage is speed.
In spirited driving, the Volvo is at a disadvantage to rear-drive sport sedans like the BMW 330i, whose weight is perfectly balanced front to rear.
Her disadvantages were many.
Their disadvantages are clear.
But the disadvantages are significant, too.
Of course, disadvantages are clear, too.
Yet its disadvantages are many more.
No disadvantages were mentioned.
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