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Of particular importance is the novel notion that that there exists a juxtamembrane cytoplasmic region surrounding FAs, characterized by higher concentrations of FA proteins (e.g., paxillin and vinculin), whose diffusion is attenuated in this environment.
The strength of the DySCo method is its ability to quantify homo- and hetero-interactions including both constitutive dimers and the much weaker interactions of transient dimers or of proteins whose diffusion is constrained by cytoskeleton-mediated corralling effects, as shown here.
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The conclusions are based solely on FRAP studies of one chaperone (BiP) under conditions of ER stress and the localization of one misfolded protein (CPY*), whose diffusion was not investigated by FRAP.
In our further work, we will consider more simple and practical methods which will be used to simulate a broader class of SDEs whose diffusion coefficient is a function of t and x.
Ideally, the thickness should be reduced even further in order to also capture so-called hot electrons, whose diffusion length is extremely short.
To show that the PIFE method proposed in this paper can also be applied to anisotropic elliptic interface problems, we provide a numerical example in this subsection, whose diffusion coefficients are piecewise symmetric definite-positive matrices (mathbb{B}^{l}), (l=pm) satisfying (mathbb{B}^= t mathbb {B}^), (t>0), (tneq1).
We hope our theory could be helpful to understand the kinetic behaviour of hydrogel during diffusion, especially for the diffusion of hydrogel in the deep sea, whose diffusion can be much accelerated by the hydraulic pressure.
The first would involve a 'default' secretion pathway, releasing monomeric or low-degree oligomeric forms of the morphogens, whose diffusion would be very limited.
The excluded patients consisted of 15 patients whose diffusion images were degraded because of magnetic susceptibility and motion artefacts, one patient with spinal canal meningioma and one patient with syringohydromyelia.
Diffusion is the valley of death for social innovation.
Ultimately, gaseous diffusion was used.
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