Accurately predicting the pace of cognitive decline would help patients and caregivers better prepare and, if treatments are developed, help doctors aggressively target those whose descent into dementia is likely to be accelerated.
Mr. Bloom likewise plays Sam's bluff, tactless father in a key that's notably different from his elderly Sam, whose descent into dementia is among the more moving sequences.
There were several lines of enquiry: Ashdown-Hill had previously used genealogical research to track down matrilineal descendants of Anne of York, Richard's older sister, whose matrilineal line of descent is extant, through her daughter Anne St Leger.
That's largely thanks to Sean Bean's role as 006, a former ally left for dead by Bond whose descent into evil is partly triggered by 007's endless thoughtless murder.
Until 1962, Edwards had mainly worked on comedies and musicals, so he seemed an unlikely choice to direct Days of Wine and Roses, in which Lee Remick and Lemmon played a married couple whose descent into alcoholism is depicted in harrowing detail.
For many, it remains his best picture, though personally I'd struggle to choose between Cinema Paradiso and Malèna, his emotional 2000 film featuring Monica Bellucci as a vulnerable widow in wartime Sicily, whose descent into prostitution is observed by a group of adolescent boys.
Mr. O'Connell, whose family is of Irish descent, is proud that they did.
Her father, who is of Chinese descent, is an architect whose firm has designed major municipal projects around town.
We Are Now Beginning Our Descent is full of sentences whose sole purpose is to keep the narrative strands apart.
But at 90 minutes, that play was far more concise and cogent than "Somewhere Fun," and more emotionally legible too: the central characters were a couple whose descent into a surreal landscape was motivated by shock at their son's near-fatal accident.
