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Following the PRR model in [13], we adopt the approximate PRR as a function of the distance, whose decreasing rate accelerates along the distance until the PRR reaches 0.5.
Both controlled and uncontrolled studies were conducted, which included a few RCTs as well as designs whose decreasing inherent ability to control for key sources of (e.g., selection) bias increasingly precludes the identification of reliable links between interventions and effects.
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It included CTBP1, whose decreased expression has been associated with migratory, invasive potential of melanoma cells [ 53].
One of these genes is BRCA1, whose decreased expression was often observed in breast cancer with epigenetic silencing and mono-allelic deletion of the BRCA1 gene [ 27- 29].
These algorithms perform particularly poorly in African Americans, whose decreased variation in VKORC1 and CYP2C9 hinders dose prediction algorithms based on variation present in European and Asian populations [ 12- 14].
There was no correlation of gene expression with tumour size, gender or age, except for ITIH5, whose decreased expression was associated with larger tumours (Spearman correlation r= −0.33 with P=0.02).
In a recent bioinformatics gene expression analysis of five cancers (breast, lung, bladder, glioma and melanoma) from eight independent studies (Rouam et al, 2010), LRIG1 was one of four genes whose decreased expression best correlated with poor survival.
Dees et al. now provide genetic evidence to support this hypothesis by characterising mice with cardiomyocyte-specific knockout of CENP-F, a multifunctional MT-binding protein whose decreased expression was recently linked to end-stage dilated cardiomyopathy in humans.
L. crispatus is a beneficial vaginal bacterium whose decrease is characteristic of bacterial vaginosis.
PDGFRα, a receptor whose decrease contributes to impaired age-associated beta cell proliferation [ 30], is a member of the beta cell 'disallowed gene' family [ 31].
One of the proteins whose decrease by both drugs alone was significant and furthermore powered by their combination is the redox-related protein SOD2.
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CEO of Professional Science Editing for Scientists @ prosciediting.com