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Brush-like macromolecules are unique polymer molecules whose conformation and physical properties are controlled by steric repulsion of densely grafted side chains.
This paper reports the stereoselective synthesis of a modified tricyclic tyrosine analogue 3, whose conformation is constrained by the covalent bonds and designed on the basis of X-ray and solution structures of SH2 domain and its natural peptide ligand.
However, anandamide is a very flexible molecule whose conformation might be strongly influenced by its environment [4].
Taken together, these studies indicate that FIT2 is a 6 transmembrane domain-containing protein whose conformation likely regulates its activity in mediating lipid droplet formation.
For example, a notable 230 nm band in α-chymotrypsin has been attributed to a tryptophan residue whose conformation is sensitive to changes in its environment upon activation of α-chymotrypsinogen to α-chymotrypsin [43].
In contrast to these PSAM structures whose conformation is maintained by two globular domains capping both ends of the β-sheet, the TCP domain stably exists on its own.
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This analysis is reported as the percentage of molecules whose conformations are recovered within a given threshold RMSD value.
Conformational sampling begins by identifying fragments from the rotamer library that are contained in the molecule of interest whose conformations need to be sampled.
This principle is here illustrated using a coarse-grained model of a family of three-helix bundle proteins whose conformations, once secondary structure has formed, can be defined by six rotational degrees of freedom.
Studies in this field have yielded a variety of complex molecular devices whose conformations are controllable by many triggering mechanisms including pressure, solvent, counter ion, redox state, and photoinduction.
The algorithm is used for an exact identification of all designing sequences of HP proteins consisting of up to 19 monomers whose conformations are represented by interacting self-avoiding walks on the simple cubic lattice.
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