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The study, known as HERS, involved women who had already had heart disease, a group in whom effects should be easiest to find.
The current literature includes 11 cohorts of children for whom effects from prenatal or neonatal PCB exposures were assessed.
In contrast to the ITT, for these analyses the estimation sample is limited to those following protocol, and for whom effects are hypothesized to be larger.
Because cancer patients are a heterogeneous collective in whom effects of mistletoe treatment on immune function and safety are compromised by the underlying disease and/or conventional therapies healthy volunteers were recruited for the clinical trial.
Even if an overall ALS clinical trial was negative, it remains possible that C9ORF72 carriers could have been a responsive sub-population in whom effects were masked by non-carriers.
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Screening participation rates are rarely reported in randomized controlled trials, such that it is impossible to know to whom effect estimates generalize.
This may have led to an insufficient statistical power to detect an effect in Europeans, in whom the effects of IPP/VPP were likely to be smaller than in Japanese subjects.
Online psychotherapy is clinically effective yet why, how, and for whom the effects are greatest remain largely unknown.
Moreover, it showed that the impact of tax increases is more marked for young adults and for members of low socio-economic groups, for whom the effects of public information and education programmes are least effective (Lewit et al, 1981; Townsend, 1987).
Our results are in contrast to the observations made with the use of in-line microfilters in critically ill children, in whom beneficial effects on hematologic, renal and respiratory function were reported [14, 16].
32 This is an important limitation, particularly for studies of patients with advanced cardiac disease in whom treatment effects are perhaps easier to detect and for whom new treatments are most likely to be of benefit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com