Sentence examples for wholesale modifications from inspiring English sources

The power to make rapid, wholesale modifications in 3-D rested mostly with big architecture firms or companies the size of Boeing, which designed its entire 777 digitally using Dassault's Catia software.

However, differences in DNA methylation due to differential expression of DNMT1 and UHRF1 would potentially occur as minor changes rather than active, wholesale modifications in DNA methylation status.

And if it turned out that the theory of natural selection could only be integrated with our new understanding of the processes of inheritance and development by a wholesale modification of its foundations, it might be best to see the new theory as a modified descendent of Darwinism, rather than Darwinism itself.

Mutations in fundamental biosynthetic pathway genes have been studied and reported to lead to differences in xyloglucan polymer composition in all three domains; this type of wholesale modification also tends to produce altered morphological and/or growth phenotypes [ 36, 49, 50], which is not what was observed in the plants studied here.

Davis wasn't simply attempting a demographic shift but wholesale behavioral modification.

Our results provide insight into the ancestral Xanthomonas genome and indicate that differentiation with respect to host- and tissue-specificity involved not major modifications or wholesale exchange of clusters, but subtle changes in a small number of genes or in non-coding sequences, and/or differences outside the clusters, potentially among regulatory targets or secretory substrates.

Nobody pays wholesale anymore.

"Wholesale," he noted.

Wholesale will be important.

And that's wholesale.

So will some wholesale markets.