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Thus, while we cannot exclude tissue-specific ageing as causal in syndrome X, the current findings suggest that the observed delay in whole body development results from other, yet undiscovered factors.
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Given the potential involvement of ciliary modifiers and the presence of cilia throughout the whole body, the development of various additional clinical manifestations should be taken into account.
Nevertheless, PDZ-RhoGEF has a prominent function in modulating insulin signaling in mouse adipose tissue, with profound effects on whole body physiology, including development of obesity and obesity-associated T2D.
These changes precede the development of whole body insulin resistance and glucose intolerance.
Visceral adipose inflammation in obesity is a major pathophysiologic risk factor for the development of whole body IR.
To explain these observations, it has been hypothesised that the nutritional environment during the critical period of perinatal development programs whole body energy homeostasis for optimal survival under nutritionally-deficient conditions.
No previous studies have demonstrated the effects of whole body CCR2 deficiency on the development of AngII-induced vascular diseases.
The development of whole body functional MR studies is underway and can potentially complement the PET/CT for better patient care.
By comparison, it has been assumed that the development of whole body regulatory mechanisms in mammals would largely eliminate this need.
Since skeletal muscle is the most abundant tissue of the body for glucose disposal, muscle sensitivity to insulin action is essential in development of whole body insulin resistance and hyperglycemia.
This mitochondrial activity attenuates the development of ectopic triacylglycerol deposits in the liver and other tissues that would otherwise contribute to the development of whole body insulin resistance and pancreatic beta cell damage.
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