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Certain studies reported data that precluded the use of WHO outcome definitions, and were not included for analysis.
*Early treatment failure, late clinical failure, or late parasitological failure according to 28 day WHO outcome classification system.
However, because the WHO outcome criteria recommend reporting the outcome for a complete cohort, the figure 67.26% is appropriate for international comparison purposes.
A recent study by Ditah et al. which focused on outcome of TB treatment in the United Kingdom, suggested that WHO outcome criteria were not adapted to low incidence industrialized countries [ 33].
Similar(55)
Despite this, studies that used WHO outcomes showed similar outcomes: 62% [5 69] of patients had successful outcomes with a 15% [9] [22] default and 10% [7] [14] death rate.
Participants who returned outcome questionnaires at the different time points and the status of those with unknown outcome (non-responders) are depicted in the flow chart (figure).
Participants who provide outcome data (R i = 1) contribute to the first summation in (3) and those who do not provide outcome data (R i = 0) contribute to the second summation.
Such attrition means that balance in baseline characteristics for those randomized may not be maintained in the subsample who has outcome data.
Assessors who conducted outcome assessments were blind to group allocation.
Staff members who obtained outcome measurements were not informed of the diet group assignment.
Health care professionals who are outcome assessors will be blinded to participants' allocation and former assessment.
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