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Availability of a smoking cessation product with stain removal or tooth whitening activity would provide an opportunity for dentists to illustrate some early measurable benefits of smoking cessation, reinforce smokers' commitment to quit and support them on the path to a stable state of not smoking.
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Therefore, there is an increasing need for new and effective agents which perform photoprotection and skin whitening activities to prevent the above skin disorders.
To survey the potentiality as human whitening agent, the depigmenting activity of aerial part of P. thunbergiana was estimated by in vivo system using melanin-procession hairless mice for 19 days.
24 Other skin-whitening agents that have antioxidant activity and melanogenesis-inhibitory effects include L-ascorbic acid and its derivatives.
Therefore, skin whitening agents can inhibit MITF transcriptional activity by decreasing TYR protein levels through MAPK-mediated MITF phosphorylation.
A second regime brought in by microscopic eye movements, operating at higher temporal frequencies, is proposed to cause whitening of input while decorrelating retinal activity (Kuang et al. 2012).
In particular, gallic acid derivatives, such as tannic acid and ellagic acid, inhibit melanogenesis or tyrosinase activity and serve as skin-whitening agents (Noh and Lee 2011; Panich et al. 2012).
Reduced glutathione (GSH) has a skin-whitening effect in humans through its tyrosinase inhibitory activity, but in the case of oxidized glutathione (GSSG) this effect is unclear.
Therefore, a good skin whitening agent would not only effectively inhibit cellular tyrosinase activity but also decrease melanin content.
Besides, the flower extract also show antioxidant capacities, which fit the trend of skin whitening agents show dual functions including anitimelanogenenic and antioxidant activities.
18 β-glycyrrhetinic acid can also inhibit the activity of tyrosine and prevent melanin growth and whitening.
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