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In conclusion, whilst observational studies cannot demonstrate causation, this meta-analysis of large, high-quality cohort studies strongly supports gout as an independent risk factor for mortality from CVD and CHD.
Whilst observational studies cannot determine causality, the evidence suggests overall negative associations at the intersection of labor migration and child mental health, but a weak association with nutritional status.
Whilst observational studies to date are far from conclusive, it is hard to see how randomised controlled trials will resolve a complex debate that is still in its infancy.
Whilst observational work suggests that spousal couples are very important in initiating and maintaining important health behaviour changes [ 42], there are very few behavioural intervention studies which recruited spousal or co-habiting couples [ 43, 44].
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Asfar et al. proposed (in a randomized controlled trial) a MAP of 65 70 mmHg as reasonable objective [82] whilst another (observational) study found that MAP values between 72 and 82 mmHg were necessary to prevent AKI in patients with septic shock and initially impaired renal function [83].
Whilst most observational studies have demonstrated inheritance of BMI through two generations, as yet, no human studies have demonstrated the relationship across three generations.
Asfar et al. proposed (in a randomized controlled trial) a MAP of 65 70 mmHg as reasonable objective [ 82] whilst another (observational) study found that MAP values between 72 and 82 mmHg were necessary to prevent AKI in patients with septic shock and initially impaired renal function [ 83].
No randomised controlled trials (RCTs) were identified in our searches, and whilst those observational studies using comparison groups or areas provided reasonably robust evidence, most did not adequately control for or discuss the problems of selection bias in both the intervention and comparison groups.
Whilst these observational measurements may be non-invasive, Hobbs [ 31] suggests that what women want is a non-invasive yet objective measurement to know how far they have progressed in labour and that midwives also want to be able to give an accurate account of how labour is progressing.
Whilst both are observational studies that could further knowledge of delayed dental healing, ONJ and bisphosphonate use, the former study design has a number of advantages.
Whilst a majority of observational studies report associations of exposure to maternal pregnancy diabetes with lower cognitive ability, there is also evidence supporting an opposite 'protective' intrauterine effect of exposure to maternal pregnancy diabetes on offspring cognitive ability.
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