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Notably, EBF3 (p = 0.04), THEM5 (p = 0.03), CTSS (p = 0.03) and TRAK2 (p = 0.02) were associated with LOAD risk under a recessive model whilst correcting for covariates, although these associations would not survive Bonferroni correction for the 60 tests performed (p < 0.0008).
We used Schwarz's Bayesian criterion (BIC) to compare the goodness-of-fit of the models, whilst correcting for the number of parameters used (Kuha 2004).
In total, 48,803 transcripts derived from Illumina Human WG-6 BeadChips were analyzed for each sample using SOLAR, whilst correcting for kinship structure.
The algorithm is based on regression modelling that uses sufficiently small windows (5 bp default) to retain high resolution whilst correcting for one or multiple experimental control measurements simultaneously.
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Whilst they corrected for potential ascertainment bias, they did not allow for the effects of modifier genes in these families and purely looked at attributable risk from BRCA1 and BRCA2 mutations alone.
Current screening approaches are unable to identify all altered samples, whilst models that attempt to correct for 'open-system' behaviour are not applicable across all diagenetic scenarios.
After the hollow cathode source, a set of three element einzel lens and XY deflecting plates are mounted so that the former arrangement allows to improve the anionic beam focus, whilst the latter allows to correct for any deflections (Fig. 1).
The stabilised receptors can be purified in large quantities, whilst retaining correct folding, thus generating reagents suitable for a broad range of structural and biophysical studies.
The last two terms of the model are used to correct for spillover effects, whilst PTF is used to correct for partial volume effects.
The aim is to find a balance in the choice of elevation mask, to reduce the propagation delays and multipath whilst maintaining good satellite geometry, and to use tomography to correct for the ionosphere and thus improve single-frequency GPS timing accuracy.
Whilst complex kinetic models have been developed in an attempt to correct for some of these factors these are based upon multiple assumptions and data acquired at 1.5 not 3T.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com