Sentence examples for while this pathway from inspiring English sources

While this pathway is getting better understood, we do not yet know the original triggers or root causes of the disease.

While this pathway operates in the cytosol and directly impacts cytosolic OMI, it is possible that p53 plays a role in our toxicity studies where the effects are initiated in the mitochondrion and lead to increased omi gene expression.

While this pathway is a prototypical example of a growth response pathway, the CWI is more akin to a stress response cascade.

As expected, pAMPK levels were markedly elevated in Drp1 cells, indicating that, while this pathway was intact and appropriately responsive, its activation was unable to correct the severe energy deficit in the face of ongoing mitochondrial fission.

Ironically, while this pathway allows the CNS to rapidly up-regulate GSH in response to an oxidative challenge, it also holds the potential to exacerbate CNS pathology via extrusion of glutamate into the extracellular space.

18 While this pathway appears to be silenced in most adult tissues, 19 it has been shown to promote the proliferation of stem cells from various tissues in the adult.

While estimating this pathway is highly uncertain and was beyond the scope of our analysis, we can make a first-order approximation to determine the likelihood that this would contribute appreciably to damages.

Increased mTOR signaling is associated with reduced lifespan, while suppression of this pathway leads to increased longevity in many different organisms [ 3, 4].

While aspects of this pathway have been reported in other studies (Dilova et al. 2002; Dubouloz et al. 2005; Komeili et al. 2000; Zhang et al. 2013), the effect that this pathway has upon ATP efflux is a novel finding.

Activation of the mTOR pathway has been detected in bladder cancer, while inhibition of this pathway blocks bladder tumorigenesis (2, 3) in animal models and is associated with durable response in some patients with advanced bladder cancer (4).

In the apoplast, Put and Spd are oxidized through a terminal process mediated by CuAOs (ATAO1, AtCuAO1), while in peroxisomes this pathway (catalysed by AtCuAO2 and AtCuAO3) is co-localized with the PAO-mediated back-conversion.