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While this hypothesis is difficult to demonstrate, we conducted a complementary theoretical approach (Supplementary Materials S4) showing that this explanation could be plausible.
While this hypothesis is sustained by several epidemiological studies, including the Dutch Hunger Winter studies44, and many animal models with different environmental stressors45, the underling mechanisms on the intergenerational inheritance of lipotoxic cardiomyopathy induced by parental HFD remain mostly unknown.
While this hypothesis remains to be further examined, especially in the context of micropinocytosis, the energetics of membrane wrapping discussed here is in line with previous studies on the endocytosis of nanoparticles with diverse physico-chemical properties4,33,39,40,41.
While this hypothesis sounds promising, it currently remains to be investigated and proven in larger multi-national cohorts.
While this hypothesis explains geologic field data, it primarily considers the sedimentary complex above a detachment horizon.
From the table, we can observe that while this hypothesis is rejected in the sample selection model, we are unable to reject it in the prenatal care model.
Similar(19)
While testing this hypothesis, we found that the daikenchuto treatment indeed significantly suppressed the development of chronic colitis-associated colon cancer in a murine experimental model, as shown in Fig. 7. Effect of daikenchuto on the development of colitis-associated cancer (CAC) in mice.
While, whether this hypothesis is reasonable or not need a further investigation.
While attractive, this hypothesis is discarded as (i) promoters of the genes involved in these processes are not sensitive to DNA topology [54], [58] and (ii) it is unlikely that the stabilization, repair and restart pathways can rescue mutations that arrest DNA synthesis.
While tantalizing, this hypothesis needs to be tested in related, but phylogenetically more primitive, salamanders.
And while research testing this hypothesis is mixed, it's clear that efforts to curb the epidemic need to involve physicians and hospitals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com